Fig. 18. 5-Aza inhibits the migration-associated protein of FLSs. (A) The protein levels of DNMT1, PTEN, MMP-9, and TIMP-1 were analyzed by western blot in AIA FLSs treated with 5-Aza. (B) The mRNA levels of PTEN, MMP-9, and TIMP-1 were analyzed by q-PCR in FLSs treated with 5-Aza. All values are expressed as the mean ± SD. ^## P<0.01 vs. normal group. ^*P<0.05, ^**P<0.01 vs. AIA group.